一个低过渡温度基于混合物的粘性补充剂,补充了切莱科西布用于骨关节炎治疗
Ana Roda1, Alexandre Paiva1, Ana Rita C Duarte1
1LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology, Caparica, 2829-516, Portugal.
International journal of pharmaceutics
|April 6, 2024
概括
这项研究开发了一种新的 hialuronic acid (HA) 和 celecoxib 凝,使用糖醇:醇混合物治疗关节炎. 该配方显示出有希望的质性质和增强的药物释放,以提高治疗效率.
科学领域:
- 生物材料科学 生物材料科学
- 类风病学 类风病学 类风病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨关节炎 (OA) 通常用氨酸 (HA) 注射和非类固醇抗炎药物 (NSAID) 治疗.
- 目前的治疗方法可能在有效性和交付方面存在局限性.
- 需要先进的粘性补充策略,将治疗剂结合起来.
研究的目的:
- 开发和描述一种新的粘度补充剂配方,将HA和celecoxib (一种NSAID) 结合起来,使用低过渡温度混合物 (LTTM).
- 评估开发的配方的风湿性质,生物相容性和药物释放动力学.
- 评估该配方作为骨关节炎治疗中增强粘度补充剂的潜力.
主要方法:
- 基于糖醇:酸盐的LTTM配方,其中包括HA和celecoxib.
- 风病学特征包括交叉频率,模块 (G',G''),零剪率粘度和剪切稀释行为.
- 使用ATDC5共细胞进行生物相容性评估.
- 在高和低清除条件下进行体外药物释放研究.
- 核磁共振 (NMR) 稳定性研究.
主要成果:
- 开发的基于LTTM的凝表现出适合粘性补充的粘性弹性特性.
- 该配方表现出与体细胞具有良好的生物相容性.
- 与PBS溶解相比,切莱可西布的释放显著增加 (6至73倍),在低清除场景中释放持续.
- 核磁共振研究证实了LTTM+HA+celecoxib (GHA+CEX) 凝在时间上的稳定性.
结论:
- GHA+CEX配方显示出作为一种具有增强治疗效率的替代粘度补充剂的潜力.
- 基于LTTM的凝可提高赛莱可西布的溶解性和可控释放.
- 这种有前途的关节炎治疗候选人的进一步体内评估是有必要的.
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