住院成年人社区感染性肺炎的微生物病因学:利用综合分子测试进行前性研究
Dagfinn Lunde Markussen1, Øyvind Kommedal2, Siri Tandberg Knoop2
1Department of Clinical Science, Bergen Integrated Diagnostic Stewardship Cluster, Faculty of Medicine, University of Bergen, Bergen, Norway; Department of Emergency Medicine, Haukeland University Hospital, Bergen, Norway.
这项研究确定了Haemophilus influenzae和呼吸道病毒是社区获得性肺炎 (CAP) 的常见原因. 综合症聚合酶连锁反应 (PCR) 面板显著改善了CAP患者的病原体检测.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 社区获得性肺炎 (CAP) 是一个重大的公共卫生挑战.
- 准确和及时的病因诊断对于有效的CAP管理至关重要.
- 现有的诊断方法在检测病原体方面可能存在局限性.
研究的目的:
- 确定住院成年人中CAP的微生物原因.
- 为了评估综合性聚合酶链反应 (PCR) 面板的诊断产量.
- 将PCR小组的性能与标准护理诊断进行比较.
主要方法:
- 在第三级护理医院进行前性研究.
- 从成年CAP患者的下呼吸道样本进行分析.
- 使用了标准护理测试和BIOFIRE® FILMARRAY®肺炎综合面板 (FAP plus).
主要成果:
- 在确认的CAP病例中,81.3%的病原体被确定.
- 血型流感 (30.7%),SARS-CoV-2 (19.3%) 和肺炎型链球菌 (16.7%) 是最常见的.
- 在48.4%的患者中检测到呼吸道病毒.
- FAP加上病原体检测率从62.8%增加到81.3%.
结论:
- 在CAP中经常发现微生物病原体.
- 血型流感和呼吸道病毒是主要的原因.
- 综合症PCR面板显著提高了CAP中的病原体检测.
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