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细菌和宿主因素参与动物性链球菌脑膜炎

Jiale Ma¹, Huizhen Wu¹, Zhe Ma²

¹MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210014, China; Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing 210014, China; WOAH Reference Lab for Swine Streptococcosis, Nanjing 210014, China.

Microbes and infection

|April 6, 2024

概括

动物传染性链球菌会导致严重的脑膜炎. 这篇评论详细介绍了像Streptococcus suis这样的细菌如何入侵身体,穿越血脑屏障,并引发炎症,帮助治疗的发展.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
神经科学是一个神经科学.

背景情况:

动物感染性链球菌是侵袭性疾病的重要原因,特别是脑膜炎,死亡率高.
病变发生涉及细菌殖民,粘膜壁垒的入侵,血流的生存和中枢神经系统的进入.

研究的目的:

审查了解脑膜炎的分子和细胞机制的最新进展,而脑膜炎是由五种主要动物性传染性链球菌引起的.
总结共同的和特定物种的致病策略.

主要方法:

关于动物性链球菌脑膜炎的最新科学文献的综述.
专注于分子和细胞事件,包括细菌生存,宿主细胞相互作用,屏障透和免疫反应.

主要成果:

机制包括血液中的细菌生存,大脑微血管内皮细胞的粘附/入侵,血脑屏障的透和神经炎症.
在Streptococcus agalactiae,S. equi亚种zooepidemicus,S. suis,S. dysgalactiae和S. iniae中确定了常见的致病主题.

结论:

了解这些机制对于开发针对链球菌脑膜炎的新疗法至关重要.
提高知识可以提高这些严重感染的风险分层和患者结果.

关键词:

血脑屏障血脑屏障血脑屏障血脑屏障血液脑脊液屏障血液脑脊液屏障脑膜炎是一种脑膜炎.动物性传染性链球菌

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