三氨酸酸子结膜下注射作为独立的炎症预防法可化后白内障手术
Neal H Shorstein1, Shannon E McCabe2, Mubarika Alavi3
1Seva Foundation, Berkeley, California.
Ophthalmology
|April 6, 2024
概括
与局部普雷迪尼索隆酸盐 (PA) 相比,在白内障手术后,结膜下注射的三氨烯酸乙 (TA) 显示,术后黄斑胀的风险较低. 黄 Glaucoma 的风险与 TA 10 mg/ml 的风险相似,但 TA 40 mg/ml 的风险增加.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
背景情况:
- 白内障手术预防通常涉及局部药物.
- 作为替代品的子结膜注射的安全性和有效性需要进一步研究.
研究的目的:
- 为了比较 subconjunctival triamcinolone 乙化物 (TA) 注射与局部普雷迪尼索隆乙酸 (PA) 对于白内障手术预防.
- 评估这些治疗方法在术后黄斑胀 (ME) 和虹膜炎以及与玻璃眼有关的事件中的有效性和安全性.
主要方法:
- 从2018年到2021年,对69832名患者进行了回顾性队列研究.
- 对比局部PA (有或没有NSAIDs) 与副结膜TA (10 mg/ml或40 mg/ml,低/高剂量).
- 评估的几率比率 (OR) ME,虹膜炎和光眼的事件手术后.
主要成果:
- 与局部PA相比,亚结节TA的ME几率较低,特别是高剂量TA10mg/ml组 (OR=0.64).
- 在高强度TA (40毫克/毫升) 服用时,发炎的几率较低.
- 低剂量10毫克/毫升的TA显示出更低的青光眼事件几率 (OR=0.69),而40毫克/毫升的TA则显示出更高的几率.
结论:
- 高剂量的副结膜TA (10毫克/毫升) 显示,术后黄斑的风险降低.
- 关于青光眼事件的安全性概况有所不同,高度的TA可能会增加风险.
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