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纳米毒理学中的血液相容性研究:血液溶解还是红色化? (一个审查)

Anton Tkachenko¹

¹BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 25250 Vestec, Czech Republic.

Toxicology in vitro : an international journal published in association with BIBRA

|April 6, 2024

概括

纳米材料可以通过血液溶解和红细胞溶解损害红细胞 (红细胞). 本综述强调了红色素作为一个关键的纳米毒理学工具,用于评估纳米材料在标准化测试协议中的血液相容性.

科学领域:

纳米毒理学研究
血液学血液学血液学
生物相容性生物相容性

背景情况:

血液相容性测试对于纳米材料安全性评估至关重要.
纳米材料与血液成分相互作用,可能导致血液溶解和免疫反应改变等不良影响.
目前缺乏纳米材料血红相容性测试的标准化指南.

研究的目的:

审查当前关于纳米材料诱导的红细胞细胞死亡的知识,重点关注血液溶解和红色化.
要总结纳米材料红毒性的分子机制.
为了比较血液溶解和红色素测试的灵敏度和效率,用于纳米材料血红相容性测试,并倡导将红色素纳入指南.

主要方法:

文献综述侧重于纳米毒理学和血液相容性研究.
对纳米材料诱导的血液溶解和红化现有数据的分析.
红色素和血液溶解试验的批判性比较,以评估纳米材料的血液兼容性.

主要成果:

纳米材料可以诱导明显的红细胞细胞死亡途径,包括红细胞病.
纳米粒子物理化学性质和红色素诱导之间的关系仍然很复杂,需要进一步研究.
红色酶测定显示承诺作为纳米毒理学血红相容性评估的敏感工具.

结论:

是纳米毒理学研究的新兴和有价值的工具.
将红色酶纳入体外血红相容性测试协议可以提高纳米材料安全性评估.
需要进一步的研究来阐明纳米粒子-属性-结关系,并标准化测试方法.

关键词:

2+) 的流入量.红细胞是红细胞.纳米毒性纳米毒性氧化应激是一种氧化应激.调节的细胞死亡.

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