在接触的矿工中,嗅觉管/泡金属度
Luis F Gonzalez-Cuyar1, Gill Nelson2, Susan Searles Nielsen3
1University of Washington, School of Medicine and Department of Laboratory Medicine and Pathology, Division of Neuropathology, 325 9th Ave, Seattle, WA 98104, USA.
Neurotoxicology
|April 6, 2024
概括
接触的矿工在嗅觉组织中可能具有更高的含量. 累积暴露,而不是最近的暴露,似乎影响了嗅道和球泡中的这些度.
科学领域:
- 神经毒理学 神经毒理学
- 职业健康 职业健康 职业健康
- 环境科学 环境科学
背景情况:
- (Mn) 是一种重要的微量营养素,具有已知的神经毒性作用.
- 职业和环境暴露可以提高全身含量.
- 空气中的粒子可以通过嗅觉通路将Mn运送到中枢神经系统.
研究的目的:
- 量化矿工的嗅觉管/球组织金属度,有或没有接触.
- 调查累积Mn暴露与嗅觉组织中Mn水平之间的关系.
主要方法:
- 诱导合等离子体质谱法 (ICP-MS) 用于测量金属度.
- 分析了来自24 Mn暴露和17名未暴露南非矿工的嗅道/气球的组织样本.
- 线性回归评估了累积Mn暴露和嗅觉Mn度之间的关联.
主要成果:
- 暴露于Mn的工人中,气味道/气球中平均度略高 (0.09μg/g在异常值排除后).
- 在累积的Mn暴露和嗅道/气泡Mn度 (0.05μg/g每毫克Mn/m3年) 之间观察到一个积极的关联.
- 最近接触的时间与嗅道/气球水平没有相关性.
结论:
- 接触Mn的矿工可能会在嗅道/气球组织中呈现较高的Mn度.
- 累积的Mn剂量似乎是一个比暴露近期更重要的因素.
- 研究结果表明,嗅觉通路是神经毒性的潜在途径.
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