相关实验视频

Updated: Jun 29, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

使用文本挖掘资源推进新蛋白质的过敏性评估

Jorge Novoa¹, Antonio Fernandez-Dumont², E N Clare Mills³

¹Computational Systems Biology Group, National Centre for Biotechnology (CNB-CSIC), 28049, Madrid, Spain.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|April 6, 2024

概括

这项研究通过分析科学文献,创造了一个新的资源,通过分析科学文献,将过敏原与他们的症状联系起来. 这有助于更好地了解蛋白质安全性和过敏症状.

科学领域:

生物医学信息学生物医学信息学
过敏基因组学过敏基因组学
计算生物学计算生物学

背景情况:

鉴于对替代蛋白质的需求日益增加,评估蛋白质的安全性,特别是对过敏原的潜力至关重要.
目前的过敏原数据库缺乏协调的临床信息,阻碍了系统研究.
缺少标准化的症状学数据,阻止与其他生物医学资源的整合.

研究的目的:

开发第一个全面的资源,注释过敏原症状学.
为未来精选编译与过敏原相关的临床数据建立基础.
提高对与过敏原相关的人类健康影响的理解.

主要方法:

在PubMed摘要 (∼3600万) 上使用了文本挖掘方法.
鉴定出过敏原和临床症状之间具有统计学意义的相关性.
从人类表型本体学和MeSH术语中提取了1,180个临床征兆.

主要成果:

将1,180个临床症状与1,036个独特的过敏原联系起来.
确定了14009种过敏原与其症状之间的关系.
为该资源开发了一个公开可用的交互式Web界面.

结论:

生成的资源提供了对过敏原症状学的全新,全面的注释.
该资源有助于将过敏原数据与健康研究的临床信息联系起来.
它作为进一步研究过敏原安全和管理的宝贵起点.

关键词:

过敏原数据库过敏原数据库过敏原的症状和症状学临床相关性临床相关性风险评估风险评估风险评估文本挖掘 (Text Mining) 是一种文字挖掘的方法.

更多相关视频

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

相关概念视频

Cross-reactivity

Cross-reactivity

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...