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Updated: Jun 29, 2025

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对大规模细胞培养生物反应器的CFD模型的验证及其在扩大规模中的应用

Zizhuo Xing1, Gearóid Duane2, Josiah O'Sullivan2

  • 1Biologics Development and Operations, Bristol Myers Squibb Company, Devens, MA 01434, USA.

Journal of biotechnology
|April 6, 2024
PubMed
概括

使用计算流体动力学 (CFD) 的基于模型的方法优化了生物反应器的混合和通风,以获得成功的细胞培养扩展. 这种方法确保了足够的氧气供应和二氧化碳剥离,从而节省了成本和时间.

关键词:
二氧化碳剥离 脱离二氧化碳计算流体动力学 计算流体动力学气体的入口速度是气体的入口速度.驱动器被洪水淹没的情况氧气需求模型的模型过程扩大规模的升级.卷度氧气转移系数 卷度氧气转移系数

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相关概念视频

Typical Model Studies01:30

Typical Model Studies

Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
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