智能奇托桑纳米凝用于向的多克索鲁比辛输送,确保精确的释放,并最大限度地减少埃里希瘤癌症携带小鼠的副作用
Magy M Abo-Ser1, El-Shahat A Toson1, Ashraf A El-Bindary1
1Department of Chemistry, Faculty of Science, Damietta University, 34517 Damietta, Egypt.
International journal of biological macromolecules
|April 6, 2024
概括
这项研究开发了一种pH敏感的奇托桑纳米颗粒/P(N-异烯胺-协同-烯酸) 纳米凝用于多克索鲁比的输送. 新型纳米凝在小鼠中表现出优异的抗癌活性,并减少了与自由多克索鲁比辛相比的副作用.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 生物聚合物纳米凝是先进的体内药物载体.
- 素纳米颗粒 (CSNPs) 和P(N-异烯胺-辅酸) 共聚物为药物输送提供了独特的特性.
研究的目的:
- 开发和评估一个对pH敏感的奇托桑纳米颗粒/P(N-异烯胺-协同-酸) 纳米凝 (CSNPs/P(NIPAm-协同-AAc)) 用于多克索鲁比辛化 (Dx. ) 的交付.
- 为了评估药物装载纳米凝的体内抗癌疗效和安全性,与自由多克索鲁比辛相比.
主要方法:
- 封装的多克索鲁比辛化 (Dx. 通过静电结合将HCl) 转化为CSNP/P(NIPAm-co-AAc) 纳米凝.
- 内注射Dx载荷纳米凝 (Dx@N.gel) 给携带埃里希瘤 (Eh) 的小鼠.
- 评估抗癌活性,生存率,氧化应激标志物和器官功能.
主要成果:
- 开发的纳米凝表现出改进的结构和响应性行为.
- 与自由Dx相比,Dx@N.gel在Eh小鼠中显示出显著增强的抗癌活性和改善的生存率.
- 纳米凝有效地减轻了氧化应激,防止肝脏DNA损伤,使酶水平正常化,并改善了并发症.
结论:
- 响应pH的CSNPs/P ((NIPAm-co-AAc) 纳米凝代表了抗瘤药物输送的有前途的进展.
- 这种纳米载体系统通过提高治疗疗效,同时最大限度地减少药物诱导的副作用,提供了潜在的范式转变.
关键词:
癌症治疗治疗 癌症治疗有控制的药物释放.纳米-奇托萨纳斯 (Nano-chitosanosan) 是一种新技术.纳米凝是一种纳米凝.P ((NIPAm-co-AAc) 的意思是"与AAc合作"的意思响应pH的反应性更多相关视频
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