在老年人中,残留胆固醇和与代谢功能障碍相关的脂肪性肝病之间的关联
Yanqi Lan1, Zhinan Guo1, Junsheng Dai2
1Xiamen Center for Disease Control and Prevention, Xiamen, Fujian, China.
概括
较高的残留胆固醇 (RC) 水平与中国老年人代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险增加有关. 监测RC对于预防和管理这群人群中的MASLD至关重要.
科学领域:
- 心血管研究研究心血管研究
- 代谢综合征研究 代谢综合征研究
- 老年医学 老年医学
背景情况:
- 剩余胆固醇 (RC) 对老年人代谢功能障碍相关的脂肪性肝病 (MASLD) 的影响尚不清楚.
- 改善晚年MASLD结果的最佳RC水平仍然含糊不清.
研究的目的:
- 调查残留胆固醇 (RC) 水平与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率和严重程度之间的联系.
- 为了检查老年中国人口中的这种关系.
主要方法:
- 分析了来自65岁及以上的131,868名受试者的数据.
- 使用后勤回归来评估RC和MASLD之间的关联,包括肝纤维化.
- 进行了分层分析,以确定潜在的相互作用效应.
主要成果:
- 随着年龄的增长,MASLD的流行率和RC度下降.
- 较高的RC水平 (最高四分位数与最低) 与MASLD (1.587;95% CI: 1.524-1.652) 的几率比率增加显著相关,即使是肝纤维化.
- 在男性,65-69岁的个体,没有中心肥胖症的个体,糖尿病患者和总胆固醇和LDL-C水平正常的人群中观察到更明显的效应.
结论:
- 升高的残留胆固醇 (RC) 水平在中国老年人群中是代谢功能障碍相关的脂肪性肝病 (MASLD) 的重要危险因素.
- 建议对老年人加强RC的监测,以帮助MASLD的预防和干预策略.
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