父亲的饮食中巨量营养素的平衡和能量摄入导致后代之间的代谢和行为差异
Angela Jane Crean1, Alistair McNair Senior1, Therese Freire1
1Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.
Nature communications
|April 6, 2024
概括
父亲的饮食影响后代的特征. 怀孕前的高脂肪饮食增加了女性后代的身体脂肪,而低蛋白/高碳水化合物饮食在男性中诱导了类似焦虑的行为.
科学领域:
- 生殖生物学 生殖生物学
- 营养科学 营养科学
- 行为遗传学行为遗传学
背景情况:
- 父亲的饮食越来越多地被认为对后代发育起作用.
- 特定的饮食成分及其影响后代表型的机制在很大程度上仍未确定.
- 营养几何学为研究宏观营养素平衡及其生物效应提供了一个框架.
研究的目的:
- 为了研究父亲在怀孕前的饮食中巨量营养素平衡对小鼠后代代代谢和行为特征的影响.
- 为了确定特定的饮食成分及其相互作用驱动对后代的父性影响.
- 为了区分宏观营养素平衡的影响与一般的营养过剩或营养不足.
主要方法:
- 在交配之前,雄性小鼠被养了十种不同的同热量饮食,蛋白质,脂肪和碳水化合物比例各不相同.
- 雌性和后代被维持在标准的食中,与实验饮食隔绝.
- 评估后代的代谢 (身体脂肪) 和行为 (类似焦虑) 特性.
主要成果:
- 父亲的脂肪消耗与雌性后代的身体脂肪增加有积极的相关性.
- 父亲的蛋白质含量低,碳水化合物含量高的饮食与男性后代的焦虑类表型有关.
- 父亲的影响是由宏观营养素平衡和能量摄入之间的相互作用调节的,而不仅仅是营养状况.
结论:
- 父亲的饮食中宏观营养素成分显著影响后代的代谢和行为表型.
- 特定的宏观营养素失衡,而不仅仅是整体能量摄入,是这些跨代效应的关键驱动因素.
- 这项研究强调了父亲营养在规划后代健康和行为的重要性.
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