使用大麻与住院Covid-19患者的较低死亡率相关使用国家住院患者样本:一项流行病学研究
Joseph-Kevin Igwe1, Ugo Alaribe2
1Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. igweresearch@gmail.com.
Journal of cannabis research
|April 6, 2024
概括
积极使用大麻与住院COVID-19患者的死亡几率明显降低有关. 这些发现表明,内分泌大麻素系统可能是COVID-19治疗的目标.
科学领域:
- 医学研究 医学研究
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 内分泌大麻素系统 (ECS) 可能为COVID-19患者提供保护性益处.
- 大麻使用 (CU) 与住院患者的COVID-19结局之间的关联仍然不清楚.
研究的目的:
- 研究大麻使用 (CU) 与住院患者的COVID-19结局之间的关系.
- 为了比较活跃大麻使用者 (ACU) 和非使用者 (N-ACU),以及CU和非使用者 (N-CU) 之间的结果.
主要方法:
- 使用2020年国家住院患者样本数据库进行多中心追溯观察队列分析.
- 包括COVID-19相关住院的成年人 (≥18岁).
- 使用多变量回归和倾向得分匹配 (PSM) 来分析死亡率,机械呼吸 (MV) 和肺栓塞 (PE).
主要成果:
- 住院治疗的COVID-19患者的死亡率更高 (13.44%) 和次要结果更差.
- 积极使用大麻 (ACU) 与COVID-19患者的MV,PE和死亡几率较低有关.
- 在PSM中,ACU与非使用者相比,死亡几率降低83.97% (aOR:0.16).
结论:
- 内分泌大麻素系统 (ECS) 可能是调节COVID-19的潜在治疗目标.
- 需要进一步的研究来验证这些发现并探索治疗影响.
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