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Updated: Jun 29, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

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Gadd45g不足驱动了骨髓增殖性瘤的病变发生

Peiwen Zhang1,2,3, Na You1,2,3, Yiyi Ding1,2,3

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Nature communications
|April 6, 2024
PubMed
概括

减少生长停滞和DNA损伤诱导性玛 (GADD45g) 表达促进骨髓增殖性瘤 (MPNs). 缺乏GADD45g会促进干细胞生长,并通过特定的信号通路驱动MPN的发展.

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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells12:04

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