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自滑,生活的隐形眼镜

María Puertas-Bartolomé^1,2, Izabook Gutiérrez-Urrutia³, Lara Luana Teruel-Enrico¹

¹INM-Leibniz Institute for New Materials, Campus D2 2, 66123, Saarbrücken, Germany.

Advanced materials (Deerfield Beach, Fla.)

|April 7, 2024

概括

新的隐形眼镜 (CL) 嵌入滑剂分泌生物工厂,不断释放氨酸 (HA),改善干眼综合征患者的滑和舒适度.

科学领域:

生物材料工程生物材料工程
眼科医生眼科眼科
隐形眼镜技术隐形眼镜技术

背景情况:

干眼综合征越来越普遍,特别是在老龄化和数字化社会.
这种情况显著影响了长期的隐形眼镜 (CL) 佩戴,并需要经常使用眼滴.
现有的CL往往无法提供足够的滑,导致不适和减少磨损时间.

研究的目的:

开发一种新的方法来增强和扩展隐形眼镜的滑性能.
引入能够自主分泌滑油的自滑CL.
为了提高长期的佩戴舒适度,减少对滑眼滴的依赖.

主要方法:

在CL水凝矩阵中嵌入滑剂分泌生物工厂.
利用生物工厂自主生产和释放氨酸 (HA),一种天然滑剂.
在镜片外围设计一个功能环,以容纳视觉轴外的生物工厂.

主要成果:

水凝矩阵成功调节了生物工厂生长和HA生产超过3周.
持续的HA释放可持续地降低了CL表面的摩擦系数.
由此产生的自滑CL原型证明了细胞相容性,并满足了商业CL的物理化学要求.

结论:

开发的自滑CLs提供了耐用设计解决方案,以提高穿戴舒适度.
这种创新方法有可能显著降低滑眼滴的需求.
制造过程与现有的CL制造相兼容,为临床应用铺平了道路.

关键词:

氨酸是什么? 氨酸是什么?这是一种水凝.滑方式滑方式智能隐形眼镜是一种智能隐形眼镜.

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Contact Angle

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The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...