CD70 - 针对高级清细胞脏细胞癌的基CART细胞疗法
Sumanta K Pal1, Ben Tran2, John B A G Haanen3,4,5
1Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, California.
Cancer discovery
|April 7, 2024
概括
化学抗原受体 (CAR) T细胞疗法对清细胞细胞癌 (ccRCC) 显示出前景. 一种针对CD70的CAR T细胞产品CTX130在I期试验中证明了安全性和有效性,实现了持久的反应.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 细胞疗法细胞疗法
背景情况:
- 清细胞细胞癌 (ccRCC) 的治疗选择有限.
- 化学抗原受体 (CAR) T细胞治疗是一种潜在的新方法,用于固体瘤.
研究的目的:
- 为了评估CTX130的安全性和疗效,一个全源的CD70向的CAR T细胞产品,在患有晚期或耐火性ccRCC的患者中.
- 探索针对CD70的CAR T细胞在治疗ccRCC和其他CD70+恶性瘤方面的潜力.
主要方法:
- 在RCC异种移植模型中对CTX130的临床前研究.
- 在16名复发/耐药ccRCC的患者中,CTX130的I期,多中心,首次在人体临床试验.
- 在临床前研究中评估下一代CAR T结构CTX131.
主要成果:
- CTX130表现出良好的临床前增殖,细胞毒性和RCC异种移植瘤的完全回归.
- 在第一阶段试验中,没有观察到剂量限制性毒性,81.3%的患者实现了疾病控制.
- 一名患者实现了持续3年的持久完整反应. CTX131显示出改善的临床前扩张和疗效.
结论:
- 异性CD70向的CAR-T细胞代表了治疗ccRCC和其他CD70+恶性瘤的概念证明.
- 这项研究为患有RCC的患者提供了第一个完整的反应,突出了CAR T细胞治疗在固体瘤中的潜力.
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