久坐不动的生活方式,体力活动和胃肠道疾病:来自孟德尔随机化分析的证据
Jie Chen1, Xixian Ruan2, Tian Fu2
1School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
EBioMedicine
|April 7, 2024
概括
休屏幕时间 (LST) 表示的久坐不动的生活方式,因果性地增加了许多胃肠道疾病的风险. 相反,中度至强度的体力活动 (MVPA) 似乎可以预防几种胃肠道疾病.
科学领域:
- 遗传学和流行病学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 身体活动,久坐不动行为和胃肠道疾病风险之间的关系尚不清楚.
- 门德尔随机化 (MR) 分析是一种强大的工具,可以使用遗传变异来调查因果关系.
- 这项研究旨在通过大规模的遗传和健康数据来澄清因果关系.
研究的目的:
- 研究休屏幕时间 (LST) 对各种胃肠道疾病风险的因果关系.
- 检查中度至强度体力活动 (MVPA) 对胃肠道疾病风险的因果关系.
- 探索这些关联中的潜在调解因素,如BMI和2型糖尿病.
主要方法:
- 通过全基因组关联研究确定了LST和MVPA的基因仪器.
- 采用多变量门德尔随机化 (MR) 来评估LST和MVPA与胃肠道疾病的关联.
- 调整了潜在的混因素,包括吸烟,BMI,腰比,2型糖尿病和禁食胰岛素.
主要成果:
- 基因预测较高的LST与多种胃肠道疾病的风险增加有关,包括反流,,IBS,IBD和肝脏/胆道疾病.
- 这些关联在很大程度上在对MVPA进行会计计算后仍然存在.
- 基因预测较高的MVPA与几种胃肠道疾病的风险降低有关,在LST调整后,这些关联在方向上保持一致.
- 体重指数和2型糖尿病被确定为LST/MVPA与某些胃肠道疾病之间的关系的重要调解者.
结论:
- 久坐不动的行为,特别是增加的LST,似乎是许多胃肠道疾病发展的因果因素.
- 促进身体活动可能会对各种胃肠道疾病产生保护作用.
- 了解BMI和2型糖尿病等代谢因素的调解作用对于有针对性的干预至关重要.
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