微生物群-肠-心轴在胆酸和心血管疾病之间的作用
Ziyi Zhang1, Tingting Lv2, Xiang Wang3
1Department of Cardiovascular Medicine, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, PR China; Department of Pharmacology, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, PR China.
概括
胆汁酸 (BAs) 影响心血管健康,疏水性BAs是有害的,而疏水性BAs是保护性的. 肠道微生物群影响这种关系,通过微生物群-肠道-心脏轴 (MGHA) 为心血管疾病 (CVD) 提供新的治疗策略.
科学领域:
- 心血管科学 心血管科学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 胆酸 (BAs) 和它们的受体存在于心血管细胞中,突出显示它们在心血管疾病 (CVD) 中的作用.
- 疏水性BAA具有心脏毒性,而水友性BAA,如ursodeoxycholic酸,具有心脏保护性,如在怀孕的肝脏内胆固醇中所见.
- 肠道微生物群 (GM) 和其代谢物,特别是二次BA,与各种心血管疾病有关,包括高血压,动脉样硬化和心力衰竭.
研究的目的:
- 通过胆酸 (BA) 代谢的镜头阐明心血管疾病 (CVD) 和肠道微生物群 (GM) 之间的复杂关系.
- 整合"微生物群-肠-心轴" (MGHA) 概念与在心脏病发病的背景下BA信号.
- 根据MGHA框架调节BA水平,为心血管疾病提出新的治疗策略.
主要方法:
- 审查和综合关于胆汁酸,肠道微生物群和心血管疾病的现有文献.
- 分析BA防水性/防水性和心脏功能之间的机械联系.
- 微生物群-肠-心轴 (MGHA) 与BA信号通路的概念整合.
主要成果:
- 胆酸受体在心血管组织中表达,调解BA对心脏和血管的影响.
- 疏水性和疏水性BA的平衡对于心血管健康至关重要;偏差有助于心脏功能障碍.
- 肠道微生物群在很大程度上塑造了二级BA池,影响了心血管风险因素和疾病进展.
结论:
- 胆汁酸在心血管疾病中起着双重作用,取决于它们的疏水性和受肠道微生物群代谢的影响.
- 微生物群-肠道-心脏轴 (MGHA) 为了解肠道微生物活动如何通过胆酸影响心血管健康提供了一个框架.
- 准胆汁酸代谢和肠道微生物群为新型心血管疾病治疗提供了一个有希望的途径.
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