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小鼠通过在补充蛋白质来源之间进行选择来调节食氨基酸平衡和能量摄入量
Kamrul Zaman1, Hee-Chang Mun1, Samantha M Solon-Biet1
1Charles Perkins Centre and School of Life & Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
The Journal of nutrition
|April 7, 2024
概括
小鼠根据蛋白质度来调整食物摄入量和素和乳清蛋白之间的选择. 当饮食蛋白质较低时,囊 (Cys) 摄入量似乎会推动蛋白质偏好转变.
科学领域:
- 营养科学 营养科学
- 动物营养 动物营养
- 饮食行为 饮食行为
背景情况:
- 饮食中的蛋白质和氨基酸 (AA) 平衡需要调整食物摄入量 (蛋白质杆,PL) 和食物选择 (补充养).
- 在不同的蛋白质度 (P%) 的可消化的能量 (DE) 中,小鼠可以选择素和乳清,两种互补的蛋白质来源.
研究的目的:
- 为了调查蛋白质杆 (PL) 是否对素和乳清有类似的作用.
- 为了确定蛋白质来源偏好是否随着蛋白质度 (P%) 的下降而变化.
- 为了确定影响蛋白质选择变化的特定氨基酸 (AAs),在不同的P%水平.
主要方法:
- 在一系列饮食蛋白度 (P7.5%-P33%) 的小鼠中测量了食物摄入量和血纤维细胞生长因子-21 (FGF21).
- 使用素或乳清的定义饮食进行直接比较.
- 进行了食品选择研究,同时可以在相同的P%水平上获得素和乳清.
主要成果:
- 蛋白质杆 (PL) 值在素 (13%) 和乳清 (10%) 中不同,素的PL幅度更大.
- 小鼠在控制P% (23%) 时更喜欢咖啡因,但在较低的P% (13%和10%) 时更喜欢乳清.
- 低P%摄入量增加了血FGF21; 囊 (Cys) 摄入量保持不变,似乎驱动了蛋白质偏好开关.
结论:
- 小鼠有效地选择了互补的蛋白质来源 (素和乳清),以保持稳定的能量和氨基酸摄入量在不同的百分比中.
- 补充低P%素饮食的囊 (Cys) 降低了血FGF21和整体食物摄入量,突出了Cys在调节摄入量的作用.
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