辅助生殖技术和产后抑郁症状:一个元分析
Si Si1, Ge Zhao1, Guang Song2
1Department of Obstetrics, The First Hospital of China Medical University, Shenyang, China.
Journal of affective disorders
|April 7, 2024
概括
辅助生殖技术 (ART) 与女性产后抑郁症状 (PDS) 的发病率较低有关. 这种联系对于晚期发病的PDS特别强烈,在分娩后三个月以上观察到.
科学领域:
- 生殖医学 生殖医学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 辅助生殖技术 (ART) 是一种主要的不孕症治疗方法.
- 对不孕妇女来说,ART治疗可能是压力的重要来源.
- ART与产后抑郁症状 (PDS) 之间的关系需要进一步研究.
研究的目的:
- 为了确定ART和PDS之间是否存在关联.
- 为了比较通过ART怀孕的女性与自发怀孕的女性中PDS发生率.
- 探索影响这种关联的潜在因素,例如产后评估的时间.
主要方法:
- 一个系统的审查和12个队列研究的元分析.
- 搜索了包括PubMed,MEDLINE,EMBASE,PsycINFO和CNKI在内的主要数据库.
- 汇集了106,338名妇女的数据 (4990名ART,101,348名自发怀孕),以比较产后一年内PDS发生率.
主要成果:
- ART受孕与PDS发生率较低有关 (OR=0.83,95% CI:0.71-0.97).
- 亚组分析显示ART和晚期PDS (产后3-12个月,OR=0.65,95%CI:0.55-0.77) 之间存在更强的关联.
- 产后评估时间被认为是发现异质性的来源.
结论:
- ART似乎与产后抑郁症状的风险降低有关.
- 对于晚期出现的PDS来说,保护作用更为明显.
- 由于潜在的混因素,需要进一步进行高质量的研究来证实这些发现.
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