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Updated: Jun 29, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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在黑色素瘤中,TRAF6通过YAP1-TFCP2信号增强PD-L1表达

Linglu Wang1, Xiaoyan Liu1, Yuhang Han1

  • 1School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.

Cancer letters
|April 7, 2024
PubMed
概括

这项研究确定TRAF6是黑色素瘤中编程死亡配体1 (PD-L1) 的关键调节者. 抑制TRAF6降低PD-L1,增强抗瘤免疫力和T细胞活性,具有潜在的治疗益处.

关键词:
在CRISPR/Cas9图书馆进行选.K63 无处不在的存在黑色素瘤是一种黑色素瘤.在PD-L1中.在TRAF6中,一个YAP1一个YAP1

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