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牛皮 (Psoralea corylifolia L.) 和其活性成分异巴瓦哈尔显示出对Mycobacterium abscessus的抗菌活性

Dan Cao¹, Zunjing Zhang², Xiuzhi Jiang¹

¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Journal of ethnopharmacology

|April 7, 2024

概括

索拉莱亚 (Psoralea corylifolia L.) 提取物及其成分异巴瓦哈尔显示出对Mycobacterium abscessus具有强大的抗菌作用. 这项研究强调了它们作为新型抗菌剂的潜力,特别是异甲.

科学领域:

植物化学植物化学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

Psoralea corylifolia L.是一种传统的草药,具有多种药用.
菌根菌 (Mycobacterium abscessus) 是一个重大挑战,因为它对常规抗生素具有耐药性.

研究的目的:

调查Psoralea corylifolia L.提取物及其化合物对Mycobacterium abscessus的抗菌功效.
为了阐明已识别的活性化合物的杀菌机制.

主要方法:

超高性能液体染色学 (UHPLC) 用于分析Psoralea corylifolia L. 提取物.
最低抑制度 (MIC) 测定以确定抗菌活性.
扫描电子显微镜 (SEM) 可视化细胞损伤.

主要成果:

90%的乙醇提取物Psoralea corylifolia L.表现出对M.的显著活性 (MIC: 156μg/mL).
异巴哈尔被确定为对临床分离物具有强烈活性的关键生物活性化合物 (MIC: 216 μg/mL,平均8 μg/mL).
异巴哈尔通过细胞膜损伤表现出快速杀菌作用,导致形态变化.

结论:

索拉莱亚 (Psoralea corylifolia L.) 提取物和异巴瓦哈尔对Mycobacterium abscessus具有相当大的抗菌潜力.
异巴哈尔的机制涉及直接破坏细菌细胞膜.
需要进一步研究异巴瓦哈尔作为对抗M.的治疗剂.

关键词:

抗微生物活性的抗菌活性.具有杀菌活性的细菌.这是Isobavachalcone.这种细菌是Mycobacterium abscessus.

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