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一个回顾性研究:探索D2胃切除术后辅助化疗的最佳患者群体

Yingsong Zheng¹, Yubo Ma², Chuhong Pang¹

¹Postgraduate Training Base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China; Department of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang, China; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou, China; Zhejiang Key Lab of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, China.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

|April 7, 2024

概括

手术后的化疗改善了晚期胃癌患者的生存率. 对男性,老年人和具有特定瘤特征 (如神经入侵或III期疾病) 的患者来说,益处最为显著.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
临床研究临床研究

背景情况:

辅助化疗 (CT) 是可切除的晚期胃癌 (GC) 的标准.
术后CT疗法的有效性因患者子组而异.
了解影响CT效益的因素对于个性化治疗至关重要.

研究的目的:

研究临床和病理因素如何影响晚期GC患者手术后CT的益处.
鉴定胃切除术后从辅助化疗中获益最多的患者子组.

主要方法:

对2060名经过治愈性胃切除术的GC患者的回顾性分析.
卡普兰-梅尔分析评估因素对CT益处的影响.
单变量和多变量考克斯回归以确定独立的预后因素.

主要成果:

手术后CT缺失是GC中预后不佳的独立预测因素.
从CT中受益的子组包括男性,老年人,正常的BMI,胃腺癌,神经/血管入侵,瘤大小≥5厘米和TNMIII期.
使用考克斯回归开发的诺莫图表显示出临床相关性.

结论:

在D2胃切除术后,术后CT显著延长了晚期GC患者的生存期.
特定的患者群体,包括男性,老年人,正常的BMI和具有晚期瘤特征的患者,经历CT的增强结果.
识别这些子组允许更有针对性和有效的辅助治疗策略.

关键词:

胃癌是什么?胃癌是什么?这个名字叫做Nomogram.手术后的化疗疗法

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