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吸烟和自闭症谱系障碍之间的多代关联:来自全国前性队列研究的研究结果
Gyeyoon Yim1, Andrea Roberts2, Kristen Lyall3
1Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
American journal of epidemiology
|April 7, 2024
概括
怀孕期间母亲吸烟可能会增加孙子患自闭症谱系障碍 (ASD) 的风险. 这项研究表明,环境暴露会影响三代人的神经发育.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 流行病学 流行病学
背景情况:
- 动物研究表明,产前暴露于烟雾会导致多代神经行为问题.
- 关于产前烟雾暴露对代际影响的人类研究有限.
研究的目的:
- 调查怀孕期间母亲吸烟与孙子患自闭症谱系障碍 (ASD) 风险之间的联系.
- 探索环境暴露的潜在跨代影响.
主要方法:
- 利用护士健康研究II的数据,包括53562名母亲/祖母和120267名孙子.
- 评估了祖母在怀孕期间的吸烟情况和孙子的自闭症诊断.
- 根据母亲在怀孕期间的吸烟情况进行调整,并根据吸烟强度分析子组.
主要成果:
- 怀孕期间祖母吸烟与孙子患ASD的几率增加了1.52倍.
- 更高的吸烟强度 (≥15支/天) 显示出更强的关联 (OR=1.93).
- 没有发现与祖父吸烟有任何关联.
结论:
- 孕期暴露在香烟烟雾中可能会在三代人中产生持续的神经发育影响.
- 研究结果表明,怀孕期间的环境侮辱可能会影响孙子的健康状况.
- 需要进一步的研究来了解这些跨代影响的机制.
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