相关实验视频

Updated: Jun 29, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

在日本人口中对功能特征的GWAS元分析

Asahi Hishida^1,2, Masahiro Nakatochi³, Yoichi Sutoh^4,5

¹Department of Public Health, Aichi Medical University School of Medicine.

Journal of epidemiology

|April 7, 2024

概括

这项研究分析了日本人的功能与全基因组相关性,确定了与估计的膜过率和血清肌素相关的众多遗传位置. 这些发现为个性化病预防策略提供了潜力.

科学领域:

遗传学是一个遗传学.
腎臟病學 (nephrology) 是一種醫學專業.
人口基因组学人口基因组学

背景情况:

东亚人,特别是日本人的功能遗传流行病学尚不清楚.
对于脏特征,存在有限的全基因组关联研究 (GWAS),之前的研究样本大小小小.
跨祖先的遗传变异性需要在日本等特定人群中进行大规模的GWAS.

研究的目的:

为了对日本人的功能特征进行大规模的GWAS元分析.
识别与估计的淋巴细胞过率 (eGFR) 和血清肌素 (SCr) 相关的新型遗传位置.
用基因组信息为个性化病预防奠定基础.

主要方法:

使用来自日本大型基因组队列研究的总结数据进行了GWAS元分析.
包括大约20万名日本参与者进行eGFR和SCr分析.
对于显著的关联,使用了严格的统计值 (P < 5 × 10-8).

主要成果:

确定了110个位点与169个与eGFR相关的变异.
确定了112个位点,有176个与SCr.相关的变异.
发现了SCr的一个新位点 (染色体7上的CD36rs146148222),远离已知的位置点.

结论:

这项针对日本受试者的GWAS元分析确定了功能的新型基因组位置.
这些发现有助于理解这种人群中脏特征的遗传结构.
这些结果可能会促进未来基于遗传信息的病个性化预防策略.

关键词:

慢性脏疾病慢性脏疾病区分的集群 36 区分的集群估计的淋巴膜过率.全基因组关联研究研究.血清中的肌氨酸.

更多相关视频

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

Transcutaneous Assessment of Renal Function in Conscious Rodents

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...