[没有急性损伤的阿西克洛维尔脑病变的临床特征]
Daisuke Kuzume1, Yuko Morimoto1, Satoshi Tsutsumi1
1Department of Neurology, Chikamori Hospital.
概括
克洛维尔 (ACV) 脑病变可以发生在没有急性损伤 (AKI) 的情况下,出现较低的紧急透析率,但恢复时间较长. 这种区分对于理解ACV毒性管理至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 基 (ACV) 脑病变是一种已知的不良反应,但没有急性损伤 (AKI) 的表现很少报告.
- 在没有功能障碍的情况下了解ACV诱导的神经毒性的临床细微差别对于准确的诊断和管理至关重要.
研究的目的:
- 确定阿西克洛维尔脑病变的临床特征,特别是在没有同时发生急性损伤 (AKI) 的患者中.
- 为了比较ACV脑病变与AKI的临床特征与没有AKI的ACV脑病变.
主要方法:
- 通过神经学症状的定义,ACV脑病变是在瓦拉基克洛维尔 (VACV) 后出现的,并在停止后有所改善.
- 定义的AKI基于在医院的前七天内超过1.5倍最低记录水平的肌素水平.
- 为了进行比较分析,将18名患者分为AKI和非AKI组.
主要成果:
- 在18名老年患者中发生了ACV脑病变,其中56.6%患有AKI.
- 非AKI组显示了较低的Ca-阻断剂使用趋势,显着较低的紧急透析率 (16.9%vs70.0%),以及临床改善的时间更长 (3.67天vs2.20天).
- 所有患者都康复了,其中55.6%接受紧急血液透析.
结论:
- 没有AKI的ACV脑病变与减少紧急透析的需求有关.
- 在ACV脑病变中没有AKI,可能与症状持续时间延长相关.
- 这些发现突出了不同的临床特征,可以为治疗决策提供信息.
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