在 3 T 时,在健康人脑中 Lac+ 测量的可重复性
Ryan Armbruster1, Neil Wilson1, Mark A Elliott1
1Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
NMR in biomedicine
|April 7, 2024
概括
由于度低,在大脑中定量乳酸是具有挑战性的. 这项研究展示了一种可重复的方法,使用长回声时间的半激光序列来在健康人脑中准确的体内乳酸测量.
科学领域:
- 神经成像是一种神经成像.
- 生物化学 生化学
- 医学物理 医学物理
背景情况:
- 在体内乳酸量化对于理解大脑和肌肉骨病理至关重要.
- 由于信号与脂质重叠,传统的1HMR光谱很难检测低乳酸度 (~0.5-1毫米),特别是在健康人群中.
- 精确的乳酸测量对于诊断和监测各种神经疾病至关重要.
研究的目的:
- 开发和验证一种可靠的方法,用于在人脑中的体内乳酸量化.
- 用一种新型磁共振成像 (MRI) 技术评估乳酸盐测量的可重复性.
- 克服传统方法在检测低乳酸信号方面的局限性.
主要方法:
- 采用半局部通过亚亚巴特选择性重定焦 (半激光) 采集,具有长回声时间 (TE = 288 ms) 和大声格尺寸 (80x70x20 mm3).
- 从水压抑的光谱中可视化和量化了乳酸和氨酸 (称为Lac+) 在1.33ppm的联合信号.
- 扫描了四名健康参与者在不同的日子,每天进行多次测量,以评估一天内和一天间的重复性.
主要成果:
- 实现了Lac+信号的清晰可视化,使健康人脑中的量化成为可能.
- 证明了高的参与者内部可重复性,变化系数 (CV) 从4%到13%不等.
- 报告Lac+度的参与者之间的CV为11%,平均值为0.53mM.
结论:
- 开发的长回声时间半激光序列与大voxel提供可重复的体内Lac+测量在健康的人类大脑.
- 这种方法为准确的乳酸量化提供了有前途的方法,有助于研究神经疾病.
- 该技术在3特斯拉时大约3.5分钟内完成测量,使其在临床上可行.
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