作为阿尔佩利西布相关毒性决定因素的身体组成指标
Eliya Shachar1,2, Ari Raphael1,2, Uriel Katz2
1Oncology Department, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel.
Breast cancer research and treatment
|April 7, 2024
概括
身体组成,包括骨肌肉密度和内脏脂肪组织,可以预测转移性乳腺癌患者的alpelisib毒性. 这些措施可能有助于个性化治疗和管理诸如高血糖和皮疹等副作用.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 代谢过程中的代谢.
背景情况:
- 身体成分是癌症患者的关键预后因素.
- 肉症 (严重的骨肌衰竭) 与糟糕的结果有关.
- 这项研究调查了身体成分在转移性乳腺癌中alpelisib毒性的作用.
研究的目的:
- 为了确定肉症和其他身体成分指标是否与alpelisib毒性有关.
- 探索身体成分和不良事件之间的关系.
- 为了确定潜在的生物标志物来预测治疗毒性.
主要方法:
- 对38名患有转移性乳腺癌和用alpelisib治疗的PIK3CA突变的妇女进行了回顾性观察分析.
- 用CT扫描通过骨肌肉在L3的横截面区域评估萨科佩尼亚.
- 对药物毒性,剂量修改和生存结果进行评估的身体组成指标.
主要成果:
- Sarcopenia 在50%的患者中存在,无论BMI.
- 较低的骨肌密度 (SMD) 与高血糖症风险增加相关 (P=0.03).
- 下部内脏脂肪组织 (VAT) 与alpelisib诱导的皮疹 (P=0.04) 和住院治疗 (P=0.04) 相关.
结论:
- SMD和VAT可以识别患有与alpelisib相关的高血糖和皮肤毒性更高风险的患者.
- 身体成分评估可能有助于个性化治疗观察和干预.
- 这些发现支持将身体成分分析纳入癌症治疗策略.
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