在左侧乳腺癌中进行的一项比较研究中,使用中度深呼吸呼吸与自由呼吸进行了对比
Anupam Muraleedharan1, Sandip Kumar Barik2, Deepak Kumar Das1
1Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, India.
Journal of the Egyptian National Cancer Institute
|April 7, 2024
概括
在左乳腺癌患者中,与活跃呼吸协调器 (ABC) 相结合的中度深呼吸持住 (mDIBH) 显著降低了心脏和LADA辐射剂量. 这种技术改善了心脏节约,但增加了治疗时间.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 中度深呼吸阻塞 (mDIBH) 已因其心脏节省益处而得到认可.
- 印度和东部地区有有限的前性研究评估mDIBH用于乳腺癌放射治疗.
- 这项研究比较了mDIBH和自由呼吸 (FB) 计划之间的剂量.
研究的目的:
- 在局部晚期左乳腺癌患者中,比较mDIBH与FB放射治疗计划的剂量测量结果.
- 评估mDIBH对有风险的器官的影响,特别是心脏和LADA.
- 评估在临床实践中实施mDIBH的可行性和权衡.
主要方法:
- 包括32名患有局部晚期左乳腺癌的患者.
- 放射治疗涉及到胸壁/乳房的25个小部分中的50 Gy,如果适用,则对隆瘤切除腔增加10 Gy.
- 所有患者都使用mDIBH与活跃呼吸协调器 (ABC) 进行治疗,并将数据与使用对联t测试的模拟FB计划进行比较.
主要成果:
- 与FB组相比,ABC组显示心脏V5,V10,V30和平均剂量的统计显著减少 (p < 0.001).
- 在ABC组 (V30和平均剂量) 中,LADA也观察到显著的剂量减少.
- 平均治疗时间为ABC-mDIBH的20分钟,而FB的10分钟.
结论:
- 在左侧乳腺癌放射治疗中,ABC引导的mDIBH显著降低了心脏,LADA和肺部的辐射剂量.
- 在mDIBH技术保持计划质量没有妥协.
- 治疗时间的延长与mDIBH方法有关.
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