根据美国食品和药物管理局不良事件报告系统数据库,评估与三醇抗真菌剂相关的心脏疾病
Jinhua Chen1, Shijun Xu2, Weijiang Yu1
1Department of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Henan Engineering Research Center for Tumor Precision Medicine and Comprehensive Evaluation, Henan Provincial Key Laboratory of Anticancer Drug Research, Zhengzhou, China.
Frontiers in pharmacology
|April 8, 2024
概括
醇抗真菌剂 (TAA) 可以引起心脏不良事件. 伊萨夫可纳似乎对心脏安全最安全,但新的未记录的副作用需要临床关注.
科学领域:
- 药物监督 药物监督 药物监督
- 心脏病学 心脏病学
- 菌类学 菌类学是指菌类学.
背景情况:
- 三醇抗真菌剂 (TAA) 对于治疗全身真菌感染至关重要.
- 增加TAA的临床使用导致报告的不良事件的增加.
- 心脏疾病是TAA治疗的一个重要问题.
研究的目的:
- 分析与五种TAA相关的心脏疾病:可纳,伏利可纳,伊特拉可纳,波萨可纳和伊萨夫可纳.
- 通过使用现实世界的数据,评估这些TAA在心脏不良事件方面的安全性.
- 识别目前药物标签上未列出的潜在的新心脏安全信号.
主要方法:
- 从2004年第一季度到2022年第三季度利用美国食品和药物管理局不良事件报告系统 (FAERS) 的数据.
- 分析了TAA相关心脏不良事件报告的临床特征.
- 使用不成比例分析 (ROR,PRR) 来检测安全信号.
主要成果:
- 在超过1000万个AE报告中,有1719个是TAA相关的心脏AE.
- 可纳,伏利可纳和伊特拉可纳占据了大多数报告.
- 与其他TAA相比,伊萨夫可纳显示出较少的严重结果和新的心脏安全信号.
结论:
- 在研究的TAA中,伊萨夫可纳可能具有更有利的心脏安全概况.
- 与TAA相关的心脏疾病可能导致严重的后果.
- 在TAA使用期间,对未记录的心脏不良事件保持警至关重要.
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