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对皮肤的内部治疗方法的系统审查
Sarah A Mullen1, Emma L Myers2, Rebecca L Brenner1
1College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
概括
像MMR疫苗和维生素D3这样的内部治疗方法对有不同的疗效. 本综述总结了62项试验,指出尽管的普遍性,但缺乏大型研究.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 基于证据的医学 基于证据的医学
背景情况:
- 反复性缺少FDA批准的治疗方法,导致不同的临床方法.
- 内部疗法是常用的,但在有效性方面缺乏共识.
- 皮肤是一种广泛的皮肤学挑战.
研究的目的:
- 系统地审查皮肤的内伤疗法随机对照试验 (RCT).
- 总结内伤治疗的疗效和不良事件.
- 确定最受研究的内伤疗法及其报告的结果.
主要方法:
- 62个随机对照试验 (RCT) 的系统审查.
- 内部治疗方法的分析,包括麻疹,疹,红疹 (MMR) 疫苗,纯化蛋白衍生物 (PPD),维生素D3和Candida抗原.
- 包括对成人和儿科人口的研究.
主要成果:
- 麻疹,疹,红疹 (MMR) 疫苗 (27-90%的完整响应),纯化蛋白衍生物 (PPD) (45-87%),Candida抗原 (25-84%) 和维生素D3 (40-96%) 是最受研究的.
- 大多数研究集中在成年人身上;只有4项专门针对儿科患者.
- 常见的副作用包括注射部位反应和类似流感的症状.
结论:
- 内部治疗证明了对反抗性的广泛有效性.
- 审查强调需要更大的,多机构的RCT.
- 目前的证据为治疗的临床医生提供了有用的总结.
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