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血糖变量的影响在患有冠状病毒疾病的重症患者中2019年:回顾性观察性研究
Emerson Boschi1, Gilberto Friedman2, Rafael B Moraes3
1Hospital Geral de Caxias do Sul, Postgraduate Program in Pneumological Sciences of Universidade Federal do Rio Grande do Sul (UFRGS); (RS, Brazil).
高血糖变化 (GV) 与COVID-19危急病患者的医院死亡率增加有关,特别是那些没有糖尿病的人. 这种变化也与更大的干预需要相关,如脏替代疗法和胰岛素.
科学领域:
- 关键护理医学 关键护理医学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 危急病患者的高血糖与不良结果有关.
- 糖尿病是一种在COVID-19患者中常见的并发症.
- 在COVID-19中使用皮质类固醇复杂化了血糖控制.
研究的目的:
- 分析COVID-19的ICU患者的血糖变化 (GV) 和医院死亡率之间的关联.
- 调查GV与其他临床结果之间的关系,包括机械呼吸,ICU停留,脏替代疗法,低血糖和医院感染.
主要方法:
- 对239名患有COVID-19的ICU患者进行了回顾性观察研究.
- 在住院的前10天收集血糖数据.
- 分析了GV与各种临床结果之间的关联.
主要成果:
- 血糖变化与非糖尿病COVID-19患者的医院死亡率有关 (OR,3.78).
- 较高的GV与增加替代疗法 (p=0.002),胰岛素 (p<0.001) 和低血糖 (p<0.001) 的需求相关.
- 鼻腔感染与中间GV四分位数相关 (p=0.02);皮质类固醇类没有显示任何关联 (p=0.21).
结论:
- 血糖变化是COVID-19危急病患者死亡率的重要预测因素,特别是在那些没有先前存在的糖尿病患者中.
- 葡萄糖病毒影响了对密集干预的要求,并与低血糖和感染等并发症有关.
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