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低对比度视力敏度测试与中心炎症有关,并预测新诊断的多发性硬化症患者的残疾发展

Ettore Dolcetti¹, Fabio Buttari^1,2, Antonio Bruno¹

¹Neurology Unit, IRCSS Neuromed, Pozzilli, Italy.

Frontiers in neurology

|April 8, 2024

概括

早期多发性硬化症 (MS) 的低对比度视觉敏度 (LCVA) 变化与增加的残疾和中枢神经系统炎症相关. 这种视觉测试可能有助于识别风险更严重的疾病过程的MS患者.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
免疫学免疫学免疫学

背景情况:

多发性硬化症 (MS) 通常会影响视觉系统的早期过程.
低对比度视敏度 (LCVA) 变化与视力损伤有关,并预测长期残疾.
LCVA在反映MS早期神经炎症和疾病进展中的作用尚不清楚.

研究的目的:

调查新诊断的复发性复发性多发性硬化症 (RR-MS) 患者的LCVA得分和临床特征之间的关联.
确定LCVA是否可以预测疾病的演变,并反映早期MS中神经炎症.
探索LCVA和脑脊液 (CSF) IL-10水平之间的关系.

主要方法:

研究了76名新诊断的RR-MS患者,没有视力障碍.
在2.5%和1.25%的对比度水平下评估LCVA.
与临床数据相关联的LCVA,包括2年的扩展残疾状况量表 (EDSS) 和多发性硬化症严重性评分 (MSSS),以及CSF IL-10水平.

主要成果:

在随访1年和2年后,LCVA和EDSS和MSSS之间观察到显著的负相关性.
在LCVA和CSFIL-10度之间发现了积极的相关性,表明与神经炎症有关.
统计分析使用混合效应模型和线性回归证实了这些关联.

结论:

新诊断的MS患者的改变LCVA与脑脊液 (CSF) 炎症有关.
LCVA作为一个有价值的参数,用于识别可能更糟糕的疾病进程的MS患者.
LCVA测试可以在MS的早期阶段提供预后见解.

关键词:

在EDSS中使用EDSS.在 IL-10 中,IL-10 是 IL-10 的代表.在LCVAVA中使用.这就是MSSSS的意义.身体残疾就是残疾.多发性硬化症多发性硬化症神经炎症是一种神经炎症.

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