在COVID-19中严重的Omicron患者中与死亡率相关的因素
Shuting Wu1, Guichan Liao1, Jingchun Mao1
1Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
Infection and drug resistance
|April 8, 2024
概括
在Omicron大流行期间的严重COVID-19患者中,低血小板计数,高白素-6和高衍生的中性粒细胞与淋巴细胞比率是死亡率的关键预测因素. 这些因素独立地导致死亡风险.
科学领域:
- 医学研究 医学研究
- 传染病 传染病 传染病
- 关键护理医学 关键护理医学
背景情况:
- 在全球范围内,COVID-19的Omicron变种导致严重的肺炎.
- 在严重的COVID-19中确定死亡风险因素对于患者管理至关重要.
研究的目的:
- 探索2022年在中国南部的Omicron大流行期间,严重肺炎患者死亡的潜在风险因素.
- 分析严重的Omicron COVID-19病例中与负面结果相关的因素.
主要方法:
- 分析了155名住院的严重COVID-19患者的临床数据 (55名未幸存者,100名幸存者).
- 生存和非生存组之间的生物标志物水平,并发症和临床结果进行了比较.
主要成果:
- 没有幸存者有较高的中性粒细胞数量,过敏的热血素T,尿素,肌素,C反应蛋白,甲素,介乐金-6,血D-二分体和dNLR.
- 没有幸存者表现出较低的淋巴细胞计数,血小板计数和专蛋白水平.
- 血小板计数<100 × 10^/L,白内素-6>100 pg/mL,dNLR>5.0独立预测死亡.
结论:
- 血小板计数,白内素-6和dNLR是严重的COVID-19中死亡率的独立预测因素.
- 这些发现有助于对严重的Omicron肺炎的风险分层和管理.
- 这些标记物的早期识别可以改善流行病环境中的患者结果.
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