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在多发性硬化症中的亚临床动脉样硬化.

Ruth Ann Marrie1,2, Ronak Patel3, Stephen Allan Schaffer1

  • 1Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Multiple sclerosis journal - experimental, translational and clinical
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概括

与没有多发性硬化症 (MS) 的患者相比,多发性硬化症患者的亚临床动脉样硬化率没有增加. 弗雷明汉得分有效地预测了这两组人的动脉样硬化风险,表明MS本身不是这种动脉疾病的直接风险因素.

关键词:
多发性硬化症是多发性硬化症.流行病学流行病学

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科学领域:

  • 心血管健康 心血管健康
  • 神经学 神经学
  • 免疫学 免疫学 免疫学

背景情况:

  • 多发性硬化症 (MS) 与缺血性心脏病的更高风险有关.
  • 传统的血管风险因素不能完全解释MS患者心血管风险的增加.

研究的目的:

  • 在缺乏传统血管风险因素的MS患者中研究亚临床动脉样硬化.
  • 确定弗雷明汉得分 (FRS) 是否在患有或没有多发性硬化症的人群中类似地预测动脉内膜介质厚度 (CIMT).

主要方法:

  • 招募了患有或没有多发性硬化症的参与者,不包括患有已有的血管疾病的参与者.
  • 使用心脏内膜介质厚度 (CIMT) 超声波评估亚临床动脉样硬化,并将其定义为CIMT≥75百分位数.
  • 利用后勤回归来分析MS,FRS和动脉样硬化之间的关联.

主要成果:

  • 在MS和非MS队列之间没有发现平均CIMT或亚临床动脉样硬化患病率的显著差异.
  • 在FRS中增加1个点与动脉样硬化的几率增加11%有关.
  • 多发性硬化症状态与亚临床动脉样硬化没有独立相关.

结论:

  • 亚临床动脉样硬化在患有多发性硬化的人群中并不比没有多发性硬化的人群更为普遍.
  • 弗雷明汉得分仍然是一个相关的动脉样硬化预测指标,独立于MS状态.