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高压氧使在急性严重性结肠炎爆发时能够过渡到口服类固醇
Megan M Hennessey1, Sara R Zelman2, Pam M Hannigan3
1Department of Internal Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
高压氧疗法 (HBO2) 可能有助于性结肠炎 (UC) 患者耐固醇转换为口服药物. 这种辅助治疗显示出治疗急性严重UC (ASUC) 和预防切除术的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 再生医学是一种再生医学.
背景情况:
- 性结肠炎 (UC) 涉及到对组织缺氧的失调反应.
- 静脉注射 (IV) 类固醇是急性严重UC (ASUC) 的标准,但高达三分之一的患者是耐火的.
- 类固醇耐药患者通常需要救援疗法,突出需要替代治疗方法.
研究的目的:
- 评估高压氧气疗法 (HBO2) 作为对类固醇耐药性急性严重性结肠炎 (ASUC) 的辅助治疗的潜力.
- 评估HBO2是否可以在ASUC患者中促进从IV转换为口服类固醇.
- 探索HBO2在阻断性UC病例中预防胆管切除术中的作用.
主要方法:
- 一个71岁的女性病例报告,患有广泛的UC耐火性,对因弗利克西马布和最初的静脉注射类固醇.
- 治疗包括输液皮松,维多利祖马布,随后,五次高压氧气疗法 (HBO2).
- 患者监测包括临床评估,C反应蛋白 (CRP) 水平和便频率.
主要成果:
- 患者最初通过静脉注射类固醇得到改善,但在过渡到口服类固醇后复发.
- 在HBO2治疗后,观察到CRP,便频率和出血的显著减少.
- 患者在开始HBO2治疗后成功从静脉输入转换为口服类固醇.
结论:
- 高压氧气疗法 (HBO2) 显示出作为ASUC患者抗标准疗法耐药的辅助治疗的潜力.
- 在具有挑战性的UC病例中,HBO2可能使得从静脉输入到口服类固醇的成功降级.
- 这种疗法可能是一个有价值的选择,以加强标准治疗,并可能避免切除肠道.
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