在慢性胃炎患者中,Helicobacter pylori会引起胃异菌症
Chao Cen1, Qiuying Du2, Bin Luo3
1Department of Gastroenterology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China.
Open life sciences
|April 8, 2024
概括
杆菌感染会破坏慢性胃炎患者的胃菌群,导致微生物组成和功能发生显著变化. 这项研究为预防H. pylori感染及其有害影响提供了基础.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 基因组学就是基因组学.
背景情况:
- 慢性胃炎 (CG) 通常与Helicobacter pylori (H. pylori) 感染有关.
- 杆菌对CG患者胃微生物群体的影响需要进一步阐明.
研究的目的:
- 为了研究H. pylori感染的CG患者胃菌群组成和功能的变化.
- 为了探索H. pylori诱导的胃失调症的致病机制.
主要方法:
- 来自H.pylori阳性 (HP_Pos) 和H.pylori阴性 (HP_Neg) CG患者的胃粘膜样本的16S核糖体RNA (16SrRNA) 基因测序.
- 操作分类单元 (OTU) 分析和微生物群落概况.
- 基因和基因组的京都百科全书 (KEGG) 功能预测的途径分析.
- 动物实验以验证功能基因丰富和病原性影响.
主要成果:
- 在HP_Pos和HP_Neg组之间观察到胃菌群组成的显著差异.
- 关键的家族包括Bacteroidetes,Proteobacteria,Firmicutes,Actinobacteria和Epsilonbacteraeota;关键的属包括Helicobacter,Lachnospiraceae_NK4A136_group,Bacteroides,Klebsiella和Pseudomonas. 这三种类型的细菌是主要的.
- 在两组之间确定了KEGG代谢途径的明显变化.
- 在小鼠中,H. pylori感染导致炎症,胃酸分泌量增加,胃活动升高和甲酸水平升高.
结论:
- 在CG患者中,H. pylori感染会诱导胃功能失调.
- 胃菌群和功能的改变有助于与H. pylori相关的病变发生.
- 这些发现支持了H. pylori根除对于预防胃病并发症的重要性.
相关概念视频
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
385
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
385
01:17Gastritis-II: Pathophysiology
322
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
322
01:30Peptic Ulcer Disease I: Introduction
166
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
166
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
578
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
578
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
399
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
399
01:23Gastritis III: Clinical Manifestations and Management
234
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
234