治疗炎症性肠病的益生菌:有足够的证据吗?
Yueying Ma1,2, Dandan Yang3, Jin Huang1,2
1Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Open life sciences
|April 8, 2024
概括
益生菌在炎症性肠病 (IBD) 中表现有前途,特别是在性结肠炎 (UC) 中,缓解维护和诱导. 然而,它们在克罗恩氏病中的有效性受到质疑.
科学领域:
- 胃肠道学和微生物学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),涉及慢性肠道炎症.
- 肠道微生物群在IBD病原发生中的作用,使人们对益生菌治疗和预防的兴趣增加.
- 在IBD中益生菌疗效的临床证据仍在争论中.
研究的目的:
- 审查目前关于益生菌治疗炎症性肠病 (IBD) 疗效的临床证据.
- 确定特定的益生菌菌株,其在UC和CD中具有证明的益处.
- 探索益生菌在IBD中的潜在作用机制.
主要方法:
- 对IBD治疗益生菌的临床研究进行了全面的文献综述.
- 在PubMed,Embase,Cochrane图书馆和Web of Science中从创立到2023年进行的搜索.
- 包括专注于益生菌用于UC和CD治疗和缓解的研究.
主要成果:
- 尼斯尔1917在维持UC缓解方面表现出有效性.
- 双杆菌和VSL#3显示了诱导轻度至中度活跃UC的缓解的证据.
- 关于益生菌对克罗恩病 (CD) 的有效性,目前还没有明确的结论.
结论:
- 特定的益生菌对UC管理有希望,但对CD缺乏证据.
- 益生菌机制可能涉及减少氧化压力,修复肠道屏障和调节免疫反应.
- 需要进一步进行强大的随机临床试验,以确认益生菌在IBD中的有效性和安全性.
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