长期COVID跨越SARS-CoV-2变种,血统和亚系
Sergio Padilla1,2,3, Christian Ledesma1, Javier García-Abellán1,2,3
1Infectious Diseases Unit, Hospital General Universitario de Elche, Alicante, Spain.
iScience
|April 8, 2024
概括
长期COVID最初影响了超过三分之一的住院SARS-CoV-2患者,症状严重程度因病毒系而异. 虽然总体而言,长期COVID的患病率在各个变种中是相似的,但特定的血统可能会影响症状的持续性和严重性.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行导致全球健康负担很大.
- 长期COVID的特点是感染后持续的症状,这是一个日益关注的问题,患病率和严重程度各不相同.
- 了解不同SARS-CoV-2变种对长期COVID发展的影响对于公共卫生战略至关重要.
研究的目的:
- 为了确定住院患者患有SARS-CoV-2感染的长期COVID的患病率.
- 评估不同SARS-CoV-2病毒系对长期COVID流行和症状严重性的影响.
- 调查与特定病毒变异相关的长期后果.
主要方法:
- 一项前性队列研究,涉及2524名因SARS-CoV-2感染住院的患者.
- 随访时间为12个月,以评估持续的症状.
- 根据SARS-CoV-2病毒谱系分层的症状患病率和严重性的分析.
主要成果:
- 在住院1个月后,35.2%的患者报告了持续的症状,随后症状下降.
- 奥米克朗变种患者最初表现出更高的症状强度,随着时间的推移,症状强度会降低.
- 特定的德尔塔 (AY.126,AY.43) 和奥米克朗 (BA.1.17,BA.2.56,BA.5.1) 血统与更严重的症状有关.
- 在主要的SARS-CoV-2变种中,长期COVID的总体患病率和严重程度是可比的.
结论:
- 长期COVID的流行和严重程度显示变化受到特定SARS-CoV-2病毒系的影响.
- 某些Delta和Omicron亚系可能与更持久和更严重的COVID后症状有关.
- 对血统特异性影响的进一步研究可以为长期COVID管理提供有针对性的干预措施.
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