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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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直接口服抗凝剂在心脏手术后的早期使用:一个回顾性队列研究.

Jung-Jin Wu1, Jessie Jiang2, Jian Ye3

  • 1Department of Pharmacy, Ridge Meadows Hospital, and Faculty of Pharmaceutical Sciences, Maple Ridge, British Columbia, Canada.

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直接口服抗凝剂 (DOAC) 被处方给30%的心脏手术后的患者,与华法林相比,在出血或住院没有显著差异. 这项研究提供了对该患者群体中DOAC使用的见解.

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科学领域:

  • 心脏病学 心脏病学
  • 药理学 药理学是指药理学的学科.
  • 临床医学 临床医学

背景情况:

  • 关于心脏手术后使用直接口服抗凝剂 (DOAC) 的文献有限.
  • 心脏手术患者经常被排除在重大临床试验之外.
  • 在心脏手术后需要早期的DOAC处方指南.

研究的目的:

  • 为了比较医院内DOAC使用与心脏手术后早期的华法林.
  • 为了确定与DOAC处方相关的因素.
  • 为了评估术后停留时间和出血事件.

主要方法:

  • 在心脏手术后接受抗凝血药物治疗的成年患者的回顾性队列研究.
  • 对照患者在DOACs与华法林.
  • 排除了具有DOAC禁忌的患者.

主要成果:

  • 在210名患者中,30%的患者在出院后接受了DOAC;70%的患者接受了华法林.
  • 阿皮克萨班是最常见的DOAC;中位数的开始是术后的第5天.
  • 两组之间在术后停留时间或住院出血方面没有显著差异.

结论:

  • 直接口服抗凝剂 (DOAC) 在心脏手术后约三分之一的患者中使用.
  • 使用DOAC与老年,较少的膜疾病,手术前使用DOAC和孤立的CABG有关.
  • 在DOAC和华法林组之间,出血和停留时间没有差异.