孟德尔的随机化调查肠道微生物群与睡眠障碍之间的因果关系
Wei Yan1, Zhenzhen Zhuang1, Yuhao Gao1
1Department of General Practice, Jinshan Hospital, Fudan University, Shanghai, China.
Frontiers in microbiology
|April 8, 2024
概括
这项研究将特定的肠道细菌与睡眠障碍联系起来. 某些细菌,如拉克诺斯皮拉菌可能会增加风险,而Coprobacter,Oscillospira和Peptococcus可能会降低睡眠障碍的风险.
科学领域:
- 微生物组研究的研究.
- 睡眠科学 睡眠科学
- 人类遗传学 人类遗传学
背景情况:
- 睡眠障碍在全球范围内越来越普遍.
- 在患有睡眠障碍的人群中观察到肠道微生物群组成的显著差异.
- 特定的肠道微生物与睡眠障碍之间的因果关系在很大程度上仍未被探索.
研究的目的:
- 调查肠道微生物群和睡眠障碍之间的潜在因果关系.
- 确定特定的肠道细菌种群,影响患上睡眠障碍的风险.
主要方法:
- 利用了来自肠道属 (18,340名欧洲人) 的MiBioGen联盟的数据.
- 从FinnGen生物库 (216,454名欧洲人) 获取睡眠障碍数据.
- 采用两个样本的孟德尔随机化来评估肠道微生物群和睡眠障碍之间的因果关系.
主要成果:
- 确定了拉克诺斯皮拉属植物与睡眠障碍风险增加之间的正相关性 (OR=1.429,p=0.032).
- 发现了Coprobacter (OR=0.797,p=0.016),Oscillospira (OR=0.745,p=0.038) 和Peptococcus (OR=0.858,p=0.039) 与睡眠障碍风险降低的负相关性.
- 在这四种肠道细菌和睡眠障碍之间建立了显著的因果关系.
结论:
- 拉克诺斯皮拉属植物与睡眠障碍的风险增加有关.
- 科普罗巴克特,奥斯基洛斯皮拉和百花球菌属与睡眠障碍的风险降低有关.
- 需要进一步的研究来阐明肠道微生物群对睡眠的影响的确切机制.
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