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造成黄色鱼 (Tachysurus fulvidraco) 大规模死亡的Streptococcus iniae的致病性及其诱导的宿主免疫反应

Hongsen Xu¹, Nengbin Zhu¹, Yiling Chen¹

¹Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, China.

Frontiers in microbiology

|April 8, 2024

概括

在Tachysurus fulvidraco养殖场的大规模死亡是由Streptococcus iniae引起的. 这项研究确定了病原体,对其基因组进行了测序,并详细介绍了其高致病性和对鱼类免疫系统的影响.

科学领域:

水生动物疾病研究研究.
鱼类病理学鱼类病理学
细菌基因组学是一种细菌基因组学.

背景情况:

在Tachysurus fulvidraco水产养殖中报告了大规模死亡的爆发.
导致这些死亡的特定病因原体以前未被确定.

研究的目的:

隔离和识别Tachysurus fulvidraco群众死亡的致病原体.
描述已识别的细菌菌株的病原性和基因组特征.
为了研究宿主对感染的免疫反应.

主要方法:

使用形态,生化和16S rRNA基因测序来隔离和识别病原体.
全基因组测序和分析Streptococcus iniae分离物 (2022SI08).
实验性挑战,组织病理学检查,先天性免疫酶活性测定和免疫基因的转录分析.

主要成果:

一种病原性Streptococcus iniae (2022SI08) 菌株被隔离和鉴定出来.
基因组显示了204个毒性和127个抗生素耐药性基因;证实了高致病性 (LD50 = 9.53 × 10^5 CFU/g).
感染造成了广泛的组织损伤,并对T. fulvidraco的先天免疫酶活动和免疫基因表达产生了显著的改变.

结论:

杆菌是导致Tachysurus fulvidraco.co.群体死亡的原因.
2022SI08菌株的基因组和病原特征为S. iniae的毒性提供了见解.
这项研究增强了对S. iniae的病变发生和鱼类宿主防御机制的理解.

关键词:

这种细菌是Streptococcus iniae.塔奇苏鲁斯 (Tachysurus fulvidraco) 是一个长尾龙.基因组表征的基因组表征.免疫反应的免疫反应.病原性病原性病原性

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