从具有优越免疫反应的猪中分离出来的乳酸细菌的分子鉴定和益生菌潜力的表征
Wenjie Ma1,2, Wenli Zhang1,2, Xinrong Wang1,2,3
1State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Frontiers in microbiology
|April 8, 2024
概括
乳酸细菌 (LAB) 显示出有前途的益生菌潜力. 菌株LR6在小鼠中显示出显著的健康益处,减少了沙门氏菌typhimurium感染的炎症和死亡率.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 乳酸细菌 (LAB) 以其健康益处和益生菌性质而闻名.
- 以前的研究表明,LAB丰富度与猪免疫反应增强之间存在相关性.
研究的目的:
- 从具有优越免疫反应的猪中分离和鉴定具有益生菌潜力的新型LAB菌株.
- 评估精选的LAB菌株的安全性和有效性,特别是针对沙门氏菌 (Salmonella typhimurium) 感染.
主要方法:
- 隔离和选来自猪的52个LAB菌株.
- 评估益生菌的特征 (聚合,抗酸/胆固醇,粘附) 和安全性 (抗生素耐药性,溶血活性,毒性因子).
- 在小鼠体内安全性和有效性研究,包括与沙门氏菌的挑战. typhimurium.
主要成果:
- 确定了14种具有高抗菌功效的LAB菌株.
- 与商业益生菌相比,大多数分离物体表现出优越的益生菌特性.
- 菌株LA6和LR6在小鼠中减轻了沙门氏菌 Typhimurium感染,LR6显著降低了死亡率.
结论:
- 选择的LAB分离物,特别是LR6,具有显著的益生菌特性.
- 口服LR6显示出促进健康和对抗细菌感染的潜力.
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