代谢疾病和COVID后疾病的风险:一个回顾性队列研究
Wubin Xie1, Heather E Hsu2,3, Paul R Shafer4
1Department of Global Health, Boston University School of Public Health, Boston, MA, USA.
medRxiv : the preprint server for health sciences
|April 8, 2024
概括
患有基线代谢障碍的个人,如糖尿病,高血压或肥胖,在SARS-CoV-2感染后面临发展新的临床后果的最高风险. 这种风险甚至增加了那些有代谢条件但没有COVID-19诊断的人.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 糖尿病,高血压和肥胖等代谢障碍很普遍,可能会增加对感染的脆弱性.
- 了解这些条件对SARS-CoV-2结果的影响对于公共卫生战略至关重要.
研究的目的:
- 调查先前存在的代谢障碍如何影响SARS-CoV-2感染后出现新的临床后果的风险.
- 在大量商业保险的美国成年人中分析这些风险.
主要方法:
- 利用了来自IBM/沃森MarketScan数据库 (2019-2021) 的 839,344 名成年人的非身份化数据.
- 根据COVID-19诊断和基线代谢障碍状态分组参与者.
- 员工倾向得分匹配和考克斯的比例危险模型来评估风险.
主要成果:
- 具有基线代谢障碍的COVID-19患者表现出新的临床后续的最高风险 (HRs 1.51-3.33).
- 具有代谢条件但没有COVID-19的个体也表现出增加的风险 (HRs1.33-2.35).
- 没有代谢条件的COVID-19患者与没有代谢条件的患者相比,风险增加 (HRs 1.34-2.85).
结论:
- 基线代谢状况显著增加了急性后SARS-CoV-2后遗症的风险.
- 无论COVID-19感染状况如何,代谢障碍患者的风险更高,这凸显了代谢健康管理的重要性.
更多相关视频
08:30Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
Published on: March 15, 2018
14.1K
06:04Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
867
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:15Diabetes: Symptoms, Diagnosis, and Complications
528
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
528
01:20Pathophysiology of Diabetes
924
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
924
01:36Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
01:19Psychoneuroimmunology: Diabetes and Cancer
28
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
28
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K