母亲的侵略是由休眠的激素敏感电路的短暂动员所驱动的
Stefanos Stagkourakis1, Paul Williams2, Giada Spigolon1
1Department of Neuroscience, Biomedicum B:4, Karolinska Institutet, Solnavägen 9, 171 65 Stockholm, Sweden.
bioRxiv : the preprint server for biology
|April 8, 2024
概括
在雌性小鼠中,母性侵略是由特定的大脑神经元 (PMvDAT) 激活的,这些神经元在哺乳期间变得活跃. 像益生素和催产素这样的激素会触发这些通常处于休眠状态的神经元,以保护幼.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 内分泌学 在内分泌学.
背景情况:
- 侵略是一种性二态的行为,在男性中很常见,在处女女性中不存在.
- 产后,雌性小鼠表现出暂时的侵略性,以保护幼免受掠食者和婴儿杀戮的侵害.
- 孕产妇激素在调节孕产妇的侵略性方面的作用尚不清楚.
研究的目的:
- 在哺乳期雌性小鼠中调查潜在的母性侵略的神经机制.
- 为了确定特定的神经元群体和参与这种行为的荷尔蒙影响.
主要方法:
- 在小鼠中利用光遗传学操纵和基因切除技术.
- 研究了腹前乳母神经元 (PMvDAT) 的作用及其对激素的反应.
- 研究了神经元激活/非激活对母亲侵略和其他母亲行为的影响.
主要成果:
- 确定了一组腹前乳母神经元 (PMvDAT) 神经元,对男性侵略至关重要,在哺乳期变得过度兴奋.
- 发现普罗拉克丁和催产素通过T型Ca2+通道激发这些PMvDAT神经元.
- 操纵PMvDAT神经元显著改变了母亲的侵略性,激活会影响其他母亲的行为.
结论:
- 一个单态的神经基质 (PMvDAT神经元) 集成激素线索,暂时激活哺乳期雌性中休眠的侵略性.
- 这种神经回路为激素调节的保护性母亲侵略的表达提供了一个机制.
更多相关视频
06:39Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
3.1K
06:40Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period
Published on: April 5, 2024
429
相关概念视频
Parental Care
11.7K
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
11.7K
Hypothalamic-Pituitary Axis
60.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.0K
Hormonal Regulation of the Menstrual Cycle
347
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
347
Regulation of Hormone Secretion
3.4K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
3.4K
Hormonal Control of the Ovarian Cycle
476
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
476
Ovarian Cycle
1.2K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.2K
