希尔函数是对输入-输出响应的清晰度的普遍霍普菲尔德障碍
Rosa Martinez-Corral1, Kee-Myoung Nam1, Angela H DePace2
1Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
bioRxiv : the preprint server for biology
|April 8, 2024
概括
希尔函数现在在生物物理上被证明是生物系统中响应敏度的普遍霍普菲尔德障碍. 这一发现为分子信号通路提供了一个基本的热力学极限.
科学领域:
- 生物物理学的生物物理.
- 系统生物学 系统生物学
- 生物化学 生物化学
背景情况:
- 希尔函数在生物学中被广泛用于模拟输入输出响应,但缺乏理论上的理由.
- 之前的应用依赖于经验数据的合适性,限制了基本的理解.
结论:
- 为希尔函数的广泛使用提供了生物物理上的理由.
- 建立了霍普菲尔德障碍作为理解细胞信息处理的关键概念.
- 突出了一个新引入的对象的数学兴趣.
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