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Updated: Jul 10, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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艾滋病毒包膜剪切剂和gp120作为免疫原来诱导牛的广泛中和抗体

Pilar X Altman1,2,3, Mara Parren1, Huldah Sang4

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

bioRxiv : the preprint server for biology
|April 8, 2024
PubMed
概括

用工程HIV Envtrimers免疫接种的奶牛显示出改变的广泛中和抗体 (bnAb) 反应. 单质gp120免疫单独没有引起bnAbs,突出显示了三元体结构对于bnAb诱导的重要性.

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Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...