超声波脉冲的重复频率优先激活不同的神经元群体,独立于细胞类型
bioRxiv : the preprint server for biology
|April 8, 2024
概括
在特定频率的脉冲横超声波选择性地影响大脑活动. 这种神经调节技术通过调整脉冲重复频率,显示了针对性神经调节的潜力.
科学领域:
- 神经科学是一个神经科学.
- 生物物理学的生物物理.
- 生物医学工程 生物医学工程
背景情况:
- 众所周知,间超声波 (TUS) 能够激活细胞信号传递并改变神经动态.
- 内在的神经元活动在特定的频率范围内运行,这表明频率选择性调制的潜力.
- 了解在生理脉冲重复频率 (PRF) 上的TUS效应对于其治疗应用至关重要.
研究的目的:
- 调查在生理PRF处脉冲超声波是否可以选择性地影响哺乳动物大脑中的神经元活动.
- 确定不同PRF对神经元激活模式的影响.
- 探索超声波引起的神经反应的细胞基础.
主要方法:
- 在清醒的小鼠中,单个运动皮层神经元的成像.
- 在10 Hz,40 Hz和140 Hz的PRF中输送0.35 MHz的超声波.
- 对神经元激活模式的分析和激发神经元和抑制神经元之间的比较.
主要成果:
- 大多数神经元都表现出单个PRF的优先激活,显示出频率选择性效应.
- 在PRF中,超声引起的反应与激发性神经元和帕瓦胺阳性内部神经元之间一致.
- 在单个神经元中观察到异质的机械敏感通道表达,与细胞特异的超声波敏感性相关.
结论:
- 生理学PRF提供了一种方法,可以通过超超声波选择性调节神经元活动.
- 单个细胞的敏感性受到机械敏感通道表达的影响,在超声波引起的效应中起着主导作用.
- 调节超声波PRFs为精确的神经调节提供了一个可行的策略.
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