在数字和生殖器的出现期间,一个祖先的空气调节格局的进化合作选择
Aurélie Hintermann1, Christopher Chase Bolt2, M Brent Hawkins3
1Department of Genetics and Evolution, University of Geneva, 30 quai Ernest Ansermet, 1211, Geneva, Switzerland.
bioRxiv : the preprint server for biology
|April 8, 2024
概括
肢体从的进化涉及重新定位基因调节. 四足动物肢体中的Hoxd基因控制起源于一个古老的Cloacal开发程序,而不是翅膀图案.
科学领域:
- 进化发育生物学 进化发育生物学
- 进行比较的基因组学.
- 脊椎动物的进化过程
背景情况:
- 从到四肢的转变是脊椎动物进化的关键事件.
- 了解数字模式机制需要研究基因调节,特别是霍克斯基因.
- 四足动物四肢中的Hoxd基因调节涉及到一个复杂的增强器景观,与鱼中的同类.
研究的目的:
- 调查霍克斯基因调控格局的进化起源和功能.
- 评估这个景观在与四肢发育中的作用.
- 为了确定肢体基因调节是否从或其他祖先结构进化.
主要方法:
- 在斑马鱼和小鼠中对Hoxd基因表达和增强剂功能的比较分析.
- 删除斑马鱼的同类调节区域,以评估对和水发育的影响.
- 检查哺乳动物尿源性鼻腔中的Hoxd基因调节.
主要成果:
- 删除斑马鱼的同源调节区域对的发育产生了有限的影响,但废除了Hoxd在cloaca中的表达.
- 同一个基因组域控制了小鼠泌尿腺鼻腔中的Hoxd基因表达,类似于四肢发育.
- 这表明,四肢调节系统是从祖先的克洛阿克程序中采用的.
结论:
- 四足动物四肢中的Hoxd基因调节是从一项先前存在的形发育计划中选择的.
- 鱼类的正统色素域可能代表了这种进化合作的早期阶段.
- 这项研究揭示了基因调节网络的深层同质性和进化可塑性.
相关概念视频
Development of the Sexual Organs in the Embryo and Fetus
681
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
681
Cis-regulatory Sequences
9.9K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
9.9K
Gastrulation
57.3K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.3K
Convergent Evolution
27.7K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.7K
Synteny and Evolution
3.3K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.3K
Neurulation
41.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.9K


