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肠道能量收获与腹腔外科手术后减肥相关
Ian Carroll1, Yunzhi Qian1, Alicia Sorgen2
1University of North Carolina at Chapel Hill.
Research square
|April 8, 2024
概括
代谢和减肥手术 (MBS) 的结果各不相同. 手术后测量肠道能量收获可以预测减肥成功,识别需要进一步支持的患者.
科学领域:
- 代谢和腹部手术的代谢和腹部手术
- 肥胖问题研究研究
- 胃肠病学 胃肠病学
背景情况:
- 代谢和减肥手术 (MBS) 对于严重肥胖是有效的,但有些患者会经历低于最佳的减肥或恢复体重.
- 肠道能量收获,或身体如何从食物中吸收卡路里,是影响MBS后减肥变化的潜在因素.
- 有限的研究已经探索了MBS后饮食,能量收获和体重结果之间的联系.
研究的目的:
- 在接受MBS的患者中,研究饮食,肠道能量收获和24个月的减肥结果之间的关系.
- 确定肠道能量收获是否可以预测MBS后的减肥成功.
- 探索潜在的诊断工具和治疗策略,为患有不良体重减轻结果的风险的患者.
主要方法:
- 炸弹热量计和饮食问卷被用来评估MBS之前和之后的卡路里吸收.
- 67名患者的便能量密度在多个时间点 (0,1,6,12,18,24个月) 测量.
- 采用多变量回归和随机森林算法来识别预测因素,并根据能量收获预测减肥结果.
主要成果:
- 肠道能量收获使用随机森林模型显著提高了减肥结果的可预测性.
- 体重减轻的患者与体重减轻的患者相比,便中的相对能量含量显著不同 (p<0.01).
- 在MBS之前,便能量含量较高 (表明能量吸收较低) 与手术后体重减轻较大有关,而饮食与能量收获的关联很小.
结论:
- 代谢和减肥手术改变了身体的能量收获能力.
- 在MBS后一个月便能量含量增加与6,12,18和24个月更好的减肥相关.
- 这些发现表明,有可能开发诊断工具来识别MBS后风险低于最佳体重减轻的患者.
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