在小鼠耳中,听觉异位神经元和II型螺旋性团异位神经元之间的GABAergic突触
Julia L Bachman1,2,3, Siân R Kitcher1,2, Lucas G Vattino4,5,6
1These authors contributed equally.
bioRxiv : the preprint server for biology
|April 8, 2024
概括
中间橄耳神经元 (MOC) 释放胺黄油酸 (GABA) 到听觉神经 afferents,调节听力. 这种GABAergic突触影响耳功能,并可能影响听觉发育和反.
科学领域:
- 神经科学是一个神经科学.
- 听觉生理学 听觉生理学
- 细胞生物学 细胞生物学
背景情况:
- 外皮毛细胞 (OHC) 通过II型螺旋质神经元 (SGN) 放大声音并传递听觉信息.
- 中间橄耳 (MOC) 效应神经元,主要是胆固醇,通过α9/α10尼古丁乙胆受体 (nAChRs) 抑制OHCs,影响耳增益和保护.
- MOC神经元也利用胺黄油酸 (GABA),GABAB自身受体调节乙胆的释放,但在尾中GABAergic信号的全部范围仍然不清楚.
研究的目的:
- 为了研究神经递质的身份和MOC在尾中的不同轴突终端的 postsynaptic目标.
- 阐明由MOC神经元形成的GABAergic突触对II型螺旋质神经元 (SGN) 的功能作用.
主要方法:
- 免疫组织化学用于识别神经递质标记物和细胞接触.
- 光学神经递质成像检测神经递质释放.
- 在毛细胞, afferent树突和 efferent轴突上进行补丁电生理学,以评估突触功能.
主要成果:
- 证明了MOC的不同轴突终端释放GABA到II型SGN的 afferent树突上.
- 在这些MOC-SGN突触处,通过GABAA受体 (GABAARs) 介导的确认后突触活性.
- 识别了GABAB受体 (GABABR) 自体受体激活,调节GABA从MOC终端释放的GABA.
结论:
- MOC的异端端子与II型SGN异端树突形成功能性GABAergic突触.
- 这种新型的GABAergic突触可能在耳发育,OHC活动微调和听觉反中发挥作用.
- 需要进一步的研究,以充分阐明在尾中的GABAergic信号传递的机制和功能.
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